Severe tissue trauma triggers the autoimmune state systemic lupus erythematous in the MRL/++ lupus prone mice.

Anam K, Amare M, Naik S, and Davis TA. Severe tissue trauma triggers the autoimmune state systemic lupus erythematous in the MRL/++ lupus prone mice. Lupus. 18(4):318-31 April, 2009

Tissue damage associated with a severe injury can result in profound inflammatory responses that may trigger autoimmune development in lupus-prone individuals. In this study, we investigated the role of a large full-thickness cutaneous burn injury on the early onset of autoimmune disease in lupus-prone MRL/++ mice.

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Extracorporeal shock wave therapy suppresses the early proinflammatory immune response to severe cutaneous burn injury

Davis TA, Stojadinovic A, Anam K, Melissa K, Amare M, Naik S, Peoples GE, Tadaki D, and Elester EA. Extracorporeal shock wave therapy suppresses the early proinflammatory immune response to severe cutaneous burn injury. International Wound Journal. 6(1):11-21 Feb, 2009

Following severe burn injury, persistent inflammation perpetuated by surface eschar, bacterial colonisation and neutrophil proteolytic activity can impede normal healing and result in further tissue damage. Extracorporeal shock wave treatment (ESWT) has been shown in the clinical setting to promote the healing of burn and difficult‐to‐heal wounds; however, the mechanism is unclear. We investigated the role of ESWT on the early proinflammatory response using a severe, full‐thickness and highly inflammatory cutaneous burn wound in a murine model.

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Differential cutaneous wound healing in injured MRL/MPJ mice

Davis TA, Amare M, Naik S and Kovalchuk A and Tadaki, D. Differential cutaneous wound healing in injured MRL/MPJ mice. Wound Repair and Regeneration. 15(4):577-88 Jul, 2007

Our results convincingly demonstrate that MRL/MpJ skin burn wounds heal with scar formation with delays in two critical wound healing events: wound closure, and myofibroblast development.

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