Epidermal development, growth control, and homeostasis in the face of centrosome amplification

Kulukian A, Vitre B, Holland A, Naik S, Cleveland D, Fuchs E. Epidermal development, growth control, and homeostasis in the face of centrosome amplification. Proceedings of the National Academy of Sciences. 112(46):E6311-E6320 Nov, 2015

The full extent to which centrosome amplification might directly contribute to human disease is poorly understood.  Our findings challenge the role for centrosome amplification in the initiation of skin tumorigenesis and demonstrate that certain tissues are better able to cope with its burden.

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The transcriptional factors Thpok and LRF are redundantly necessary for helper T cell differentiation.

Carpenter A, Grainger JR, Xiong Y, Chu HH, Wang L, Naik S, Dos Santos L, Wei L, Jenkins MK, O’Shea J, Belkaid Y, Bosselut R. The transcriptional factors Thpok and LRF are redundantly necessary for helper T cell differentiation. Immunity. 37(4):622-33 Oct, 2012

T helper (Th) cells are critical for defenses against infection and recognize peptides bound to class II major histocompatibility complex (MHC II) molecules. Although transcription factorshave been identified that direct Th cells into specific effector fates, whether a “master” regulator controls the developmental program common to all Th cells remains unclear. Here, we showed that the two transcription factors Thpok and LRF share this function.

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GATA3 controls Foxp3⁺ regulatory T cell fate during inflammation in mice.

Wohlfert EA, Grainger JR, Bouladoux N, Konkel JE, Oldenhove G, Ribeiro CH, Hall JA, Yagi R, Naik S, Bhairavabhotla R, Paul WE, Bosselut R, Wei G, Zhao K, Oukka M, Zhu J, Belkaid Y. GATA3 controls Foxp3⁺ regulatory T cell fate during inflammation in mice. J Clin Invest. 121(11):4503-15 Nov, 2011

Our data indicate that GATA3 limits Treg polarization toward an effector T cell phenotype and acquisition of effector cytokines in inflamed tissues. Overall, our work reveals what we believe to be a new facet in the complex role of GATA3 in T cells and highlights what may be a fundamental role in controlling Treg physiology during inflammation.

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