Epidermal development, growth control, and homeostasis in the face of centrosome amplification

Kulukian A, Vitre B, Holland A, Naik S, Cleveland D, Fuchs E. Epidermal development, growth control, and homeostasis in the face of centrosome amplification. Proceedings of the National Academy of Sciences. 112(46):E6311-E6320 Nov, 2015

The full extent to which centrosome amplification might directly contribute to human disease is poorly understood.  Our findings challenge the role for centrosome amplification in the initiation of skin tumorigenesis and demonstrate that certain tissues are better able to cope with its burden.

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Commensal-dendritic cell interactions specifies a unique protective skin immune signature.

Naik S*, Bouladoux N*, Linehan J, Han SJ, Harrison OJ, Wilhelm C, Conlan S, Himmelfarb S, Byrd A, Deming C, Quinones M, Brenchley JM, Kong H, Tussiwand R, Murphy KM, Merad M, Segre JA and Belkaid Y. Commensal-dendritic cell interactions specifies a unique protective skin immune signature. Nature. 520(7545): 104-108 April 2015.

Here we show that defined commensals dominantly affect skin immunity and identify the cellular mediators involved in this specification.This interaction may represent an evolutionary means by which the skin immune system uses fluctuating commensal signals to calibrate barrier immunity and provide heterologous protection against invasive pathogens. These findings reveal that the skin immune landscape is a highly dynamic environment that can be rapidly and specifically remodelled by encounters with defined commensals, findings that have profound implications for our understanding of tissue-specific immunity and pathologies.

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