Impaired signaling between epidermal and dendritic epidermal T cells slows wound repair in aging

Keyes B*, Liu S*, Asare A, Naik S, LevorseJ, Nikolova M, Pasoli A and Fuchs E. Impaired signaling between epidermal and dendritic epidermal T cells slows wound repair in aging. Cell.167(5)1323-1338 Nov, 2016.

Aged skin heals wounds poorly, increasing susceptibility to infections. Restoring homeostasis after wounding requires the coordinated actions of epidermal and immune cells. Here we find that both intrinsic defects and communication with immune cells are impaired in aged keratinocytes, diminishing their efficiency in restoring the skin barrier after wounding.

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