Inflammatory memory sensitizes skin epithelial stem cells to tissue damage.

Naik S*, Larsen SB*, Gomez N, Alaverdyan K, Sendoel A, Polak L, Kulukian A, Chai S and Fuchs E. Inflammatory memory sensitizes skin epithelial stem cells to tissue damage. *Equal author contribution. Corresponding author. Nature. 550(7677): 475-480 Oct 2017

Here we report that acute inflammation trains epithelial stem cells to respond faster to subsequent stressors. This work is the first to identify inflammatory memory in a non-immune cells and has significant implications for our understanding of inflammatory diseases and cancer.

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Tregs Expand the Skin Stem Cell Niche.

Horsley V and Naik S. Tregs Expand the Skin Stem Cell Niche. Developmental Cell. 41(5):455-456 June, 2017

Regulatory T cells (Tregs) are emerging as an essential stem cell niche component that promotes wound repair in adipose, muscle, and lung tissues. Recently in Cell, Ali et al. (2017) report that skin resident Tregs facilitate the proliferation and differentiation of hair follicle stem cells through Notch signaling.

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Translation from Unconventional 5’ Start Sites Drives Tumor Initiation

Sendoel A, Dunn J, Gonzales E, Naik S, Gomez N, Hurwitz B, Levorse J, Dill BD, Schramek S, Molina H, Weissman J and Fuchs E. Translation from Unconventional 5’ Start Sites Drives Tumor Initiation. Nature. 541(7638):494-499 Jan, 2017

We are just beginning to understand how translational control affects tumour initiation and malignancy. Here we use an epidermis-specific, in vivo ribosome profiling strategy to investigate the translational landscape during the transition from normal homeostasis to malignancy.

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