Fanning the Flames: IRAK2 Signaling in Differentiated Epithelium Potentiates Skin Inflammation

October 01, 2021

Rochelle Castillo, Ipsita Subudhi, Shruti Naik

Journal of Investigative Dermatology

Aberrant epidermal differentiation is a hallmark of inflammatory skin diseases, including psoriasis and atopic dermatitis. If and how differentiated epidermal cells contribute to inflammatory pathology is unclear. In their new article in the Journal of Investigative Dermatology, Shao et al. (2021) report that IRAK2 signaling downstream of IL-1 and IL-36 links epidermal differentiation and skin inflammation.