Fanning the Flames: IRAK2 Signaling in Differentiated Epithelium Potentiates Skin Inflammation
October 01, 2021
Rochelle Castillo, Ipsita Subudhi, Shruti Naik
Journal of Investigative Dermatology
Aberrant epidermal differentiation is a hallmark of inflammatory skin diseases, including psoriasis and atopic dermatitis. If and how differentiated epidermal cells contribute to inflammatory pathology is unclear. In their new article in the Journal of Investigative Dermatology, Shao et al. (2021) report that IRAK2 signaling downstream of IL-1 and IL-36 links epidermal differentiation and skin inflammation.