Neu(ronal) Custodians of Cutaneous Immunity

April 15, 2021

Kody Mansfield, Shruti Naik

Sensory neurons have surfaced as key instigators of skin inflammation. In this issue of Cell, Zhang et al. define an anti-inflammatory Langerhans cell (LC)-neuron-mast cell (MC) circuit that underlies skin immune homeostasis. They uncover a role for LCs in maintaining innervation of MrgprD+nonpeptidergic neurons that restrain MC activation via glutamate secretion.