Specific gut commensal flora locally alters T cell tuning to endogenous ligands.

Pascal C, Bouladoux N, Naik S and Schwartz R. Specific gut commensal flora locally alters T cell tuning to endogenous ligands. Immunity. 38(6):1198-210 June, 2013

These findings define a key role for the gut commensal flora in sustaining ongoing autoimmune responses through the local fine tuning of T-cell-receptor-proximal activation events in autoreactive T cells.

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Microbiota and T lymphocytes: the best enemies.

Bouladoux N, Hand TW*, Naik S*, Belkaid Y. Microbiota and T lymphocytes: the best enemies. Med Sci (Paris). 29(4):349-52Apr, 2013

(Article in French) The cells of our body coexist permanently with an extremely dense and varied microbial flora. This microbiota colonizes the surface of our skin and most of our mucous membranes, especially the intestinal mucosa.

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Preserving immunogenicity of lethally irradiated viral and bacterial vaccine epitopes using a radioprotective Mn(2+)-peptide complex from Deinococcus.

Gaidamakova EK, Myles IA, McDaniel DP, Fowler CJ, Valdez PA, Naik S, Gayen M, Gupta P, Sharma A, Glass PJ, Maheshwari RK, Datta SK, Daly MJ. Preserving immunogenicity of lethally irradiated viral and bacterial vaccine epitopes using a radioprotective Mn(2+)-peptide complex from Deinococcus. Cell Host Microbe. 12(1):117-24 Jul, 2012

We demonstrate the use of a reconstituted manganous peptide complex from the radiation-resistant bacterium Deinococcus radiodurans to protect protein epitopes from radiation-induced damage and uncouple it from genome damage and organism killing.

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