Dr. Jack Major

Postdoctoral Fellow

Jack received his B.Sc in Immunology from the University of Glasgow, before moving to the Francis Crick Institute/Imperial College London in the lab of Andreas Wack for his graduate research. During his Ph.D., Jack studied the interface between innate antiviral immunity and lung tissue regeneration, identifying a novel mechanism of immunopathology in respiratory viral infection. In 2022, Jack received an EMBO Fellowship to study homeostatic immunity in the gut and moved to the Naik lab at NYU Langone, where he currently studies neuroimmune crosstalk in inflammation and during tissue regeneration.

Selected Publications:

Major, J. et al. (2020). Type I and III interferons disrupt lung epithelial repair during recovery from viral infection. Science 369, 712–717Biddau, M., Bouchut, A., Major, J., Saveria, T., Tottey, J.* et al. (2018). Two essential Thioredoxins mediate apicoplast biogenesis, protein import, and gene expression in Toxoplasma gondii. PLoS Path. 14, e1006836

Major J, Crotta S, Finsterbusch K, Chakravarty P, Shah K, Frederico B, D’Antuono R, Green M, Meader L, Suarez-Bonnet A, Priestnall S, Stockinger B, Wack A. Endothelial AHR activity prevents lung barrier disruption in viral infection. Nature. 2023 Sep;621(7980):813-820. Epub 2023 Aug 16. PMID: 37587341; PMCID: PMC7615136.