Dr. Jack Major

Postdoctoral Fellow

Jack obtained his Bachelor of Science in Immunology at the University of Glasgow, subsequently joining Andreas Wack’s lab at the Francis Crick Institute for graduate research. His doctoral studies focused studied the interface between innate antiviral immunity and lung tissue repair, leading to the discovery of a previously unknown mechanism of immunopathology in respiratory viral infections. A second project explored a gut-lung axis that regulates disease tolerance mechanisms in the respiratory endothelium mediated by aryl hydrocarbon receptor signaling. In 2023, Jack joined the Naik laboratory as a postdoctoral fellow. His current research focuses on neuroimmune interactions in the skin, supported by an EMBO Postdoctoral Fellowship.

Selected publications:

1. Major, J. et al. Endothelial AHR activity prevents lung barrier disruption in viral infection. Nature 621, 813–820 (2023).

2. Major, J. & Naik, S. Staphylococcus scratches its itch. Cell 186, 5201–5202 (2023).

3. Major, J. et al. Type I and III interferons disrupt lung epithelial repair during recovery from viral infection. Science 369, 712–717 (2020).