The body’s barrier tissues—the skin, gut, and lungs—are where we meet the world. Our laboratory works at the intersection of immunology and regenerative medicine to understand how these organs sense changes in their environment, remember past encounters, and rebuild after injury. Through this work, we uncover fundamental principles that govern tissue resilience, repair, and memory. Our goal is to harness these insights to repair tissue damage, temper harmful inflammation, and develop durable therapies for patients with inflammatory and autoimmune diseases. Our work centers on four interconnected areas: