Fanning the Flames: IRAK2 Signaling in Differentiated Epithelium Potentiates Skin Inflammation
Rochelle Castillo, Ipsita Subudhi, Shruti Naik
Aberrant epidermal differentiation is a hallmark of inflammatory skin diseases, including psoriasis and atopic dermatitis. If and how differentiated epidermal cells contribute to inflammatory pathology is unclear. In their new article in the Journal of Investigative Dermatology, Shao et al. (2021) report that IRAK2 signaling downstream of IL-1 and IL-36 links epidermal differentiation and skin […]
Journal of Investigative Dermatology
October 01, 2021
Neu(ronal) Custodians of Cutaneous Immunity
Kody Mansfield, Shruti Naik
Sensory neurons have surfaced as key instigators of skin inflammation. In this issue of Cell, Zhang et al. define an anti-inflammatory Langerhans cell (LC)-neuron-mast cell (MC) circuit that underlies skin immune homeostasis. They uncover a role for LCs in maintaining innervation of MrgprD+nonpeptidergic neurons that restrain MC activation via glutamate secretion.
April 15, 2021
New Dog, Old Tricks: Developmental Programs Resurface in Inflammation
Daniel Rosenblum, Shruti Naik
Cellular cartography of human tissues has provided unprecedented insight into health and disease. In a recent issue of Science, Reynolds et al. (2021) use single-cell transcriptomics to define cell states and gene programs in human skin and uncover fetal programs in dermatological diseases that may fuel inflammatory pathology.
Cell Stem Cell
April 01, 2021
A Neu(ronal) Player Joins the T Regulatory Game
Samantha B Larsen
The enteric nervous system is surfacing as a key regulator of intestinal immunity and a liaison of host-commensal interactions. In this issue, Yan et al. identify neuronal interleukin-6 as a potent modulator of regulatory T (Treg) cells in the intestine. This neuroimmune dialog is further refined by commensal microbiota, which impact the enteric nervous system […]
Immunity
March 09, 2021
Warp Speed Ahead! Technology-Driven Breakthroughs in Skin Immunity and Inflammatory Disease
Piotr Konieczny, Shruti Naik
The skin’s physical barrier is reinforced by an arsenal of immune cells that actively patrol the tissue and respond swiftly to penetrating microbes, noxious agents, and injurious stimuli. When unchecked, these same immune cells drive diseases such as psoriasis, atopic dermatitis, and alopecia. Rapidly advancing microscopy, animal modeling, and genomic and computational technologies have illuminated […]
Journal of Investigative Dermatology
January 14, 2021
Trained Immunity, Tolerance, Priming and Differentiation: Distinct Immunological Processes
Community White Paper
The similarities and differences between trained immunity and other immune processes are the subject of intense interrogation. Therefore, a consensus on the definition of trained immunity in both in vitro and in vivo settings, as well as in experimental models and human subjects, is necessary for advancing this field of research. Here we aim to […]
Nature Immunology
December 08, 2020
Under Pressure: Stem Cell-Niche Interactions Coordinate Tissue Adaptation to Inflammation
Yue Xing and Shruti Naik
Stem and progenitor cells (SCs) are emerging as key drivers of tissue adaptation to inflammation caused by microbes, injury, noxious agents, and other onslaughts. These pressures are most acutely experienced in epithelial tissues such as the skin and gut that interface with the external environment. Thus, here we review how epithelial SCs of the skin […]
Current Opinion Cell Biology
September 08, 2020
Introductions to the Community: Early-Career Researchers in the Time of COVID-19: Greater than the Sum of Its Parts
Shruti Naik
COVID-19 has unfortunately halted lab work, conferences, and in-person networking, which is especially detrimental to researchers just starting their labs. Through social media and our reviewer networks, we met some early-career stem cell investigators impacted by the closures. Here, they introduce themselves and their research to our readers.
Cell Stem Cell
September 03, 2020
Deciphering The Regulatory Landscape of Fetal and Adult γδ T-Cell Development at Single-Cell Resolution
Sagar 1, Maria Pokrovskii 2, Josip S Herman 1 3 4, Shruti Naik 5, Elisabeth Sock 6, Patrice Zeis 1 3 4, Ute Lausch 7, Michael Wegner, Yakup Tanriver, Dan R Littman, Dominic Grün
γδ T cells with distinct properties develop in the embryonic and adult thymus and have been identified as critical players in a broad range of infections, antitumor surveillance, autoimmune diseases, and tissue homeostasis. Despite their potential value for immunotherapy, differentiation of γδ T cells in the thymus is incompletely understood. Here, we establish a high-resolution […]
EMBO Journal
July 01, 2020
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