Cis-regulatory arbitrators of regeneration

September 06, 2023

Piotr Konieczny, Shruti Naik

Cell Stem Cell

Mammals favor healing with scaring over functional tissue regeneration.1 In this issue of Cell Stem Cell, Mack et al. use “super-healer” mice to identify cis-regulatory variations that direct regenerative versus fibrotic gene expression in wound fibroblasts and they uncover complement factor H as a molecular driver of skin regeneration.